Simple Education: Advances in Intravascular Imaging, March 2017

2 day course from March 6-7th 2017 London, W2 2EA

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The Simple Education team have run many successful courses over the last five years, demystifying the use of coronary physiology in the cath lab for thousands of doctors from around the world.

Using a mixture of practical hands-on teaching, interactive learning aids, approachable tutors, internationally renowned lecturers and live interactive cases from cath labs in Europe, this course aims to take a new look at a key technology in the modern cath lab.


Dr Andrew Sharp

Royal Devon & Exeter

Prof Carlo Di Mario

Royal Brompton,

Prof Takashi Akasaka

Wakayama Medical University ,

Prof Patrick Serruys

Imperial College,
London, UK

Agenda: Monday 6th March 2017

09.00 – 09.10
Welcome and introductions
Andrew Sharp & Carlo Di Mario, Course Directors
09.10 – 09.40
What is IVUS? What evidence is there for clinical benefit?
Allen Jeremias
09.40 – 10.00
Case examples to explain the evidence - ST/LMS/ISR/FMJ
Carlo Di Mario
10.00 – 10.40
Breakout session 1 (20 min each)
GRP 1: Normal anatomy and vessel landmarks
                 Robert Gerber
GRP 2: Making measurements
                 Jurgen Ligthart

10.40 – 11.00
Coffee break with demonstrated measurements

11.00 – 11.40
Breakout session 2 (20 min each)
GRP 1: Common abnormalities: Calcium, Dissection, Thrombus
                 Robert Gerber
GRP 2: Typical 'False positive' images
                 Jurgen Ligthart
11.40 – 12.30
Live case transmission from Madrid – IVUS guided PCI
Operator: Javier Escaned
Moderator: Patrick Serruys
12.30 – 13.00
Left main PCI - why use IVUS and how do we use the data provided?
Nieves Gonzalo

13.00 – 14.00
Lunch - hands-on catheter assembly  in breakout rooms 1 and 2


14.00 – 14.30
How to optimise stent implantation using IVUS - three examples of tailoring IVUS results to the vessel
 Takashi  Akasaka
14.30 – 15.00
How calcification affects PCI and how IVUS can help us
Allen Jeremias
15.00 – 15.25
Does a better technical result from IVUS-guided PCI mean value for money?
Manesh Patel

15.25 – 15.40
Coffee break

15.40 – 16.00
Stent failures 1 - Identifying causes of restenosis
Takashi Akasaka
16.00 - 16.45
Intravascular Imaging: a Glacovian appraisal of the ABSORB II trial
Patrick Serruys
16.45Close of the Day 1
Course Dinner

Tuesday 7th March 2017

09.00 – 09.10
Welcome and introductions
Andrew Sharp & Carlo Di Mario, Course Directors
09.10 – 09.40
Stent failures 2 - Identifying causes of stent thrombosis
Nieves Gonzalo
09.40 – 10.00
IVUS has a unique role in CTO and we must learn these skills
Carlo Di Mario

10.00 – 10.30
Coffee break

10.30 – 11.00
Co-registration of IVUS and angiography - Syncvision
Andrew Sharp
11.00 – 11.55
Live case transmission from Hammersmith Hospital – Syncvision case
Operators: Iqbal Malik and Sayan Sen
12.00 – 12.45
Live case in a box: Co-registration of the future - angiography, imaging and physiology from a single case
Rasha Al-Lamee

12.45 – 13.45
Lunch - using the equipment towers in breakout rooms 1 and 2


13.45 – 14.15
The practical aspects of running an IVUS programme - training, equipment and procedure volumes
Nieves Gonzalo
14.15 – 14.45
Comparing IVUS and OCT - competitors, or complementary?
Javier Escaned
14.45 - 15.15 
The future of intravascular imaging
Patrick Serruys
15.30Close of the meeting

Dr Justin Davies

Dr Andrew Sharp is a Consultant Interventional Cardiologist at the Royal Devon and Exeter Hospital and Honorary Senior Lecturer at the University of Exeter in South West England. He trained in Edinburgh, London and Milan, and was awarded a research MD for his work on the hypertensive heart whilst at Imperial College. He is current departmental lead in Exeter for cardiac cath labs, hypertension and cardiac research

He currently leads research studies in the areas of coronary physiology, pharmacological management of hypertension, renal denervation, intra-coronary imaging, complex PCI, aortic valve disease and pulmonary embolus.

Dr Javier Escaned

Prof Carlo Di Mario is currently Professor of Cardiology, University of Florence and Director of the Structural Interventional Cardiology Division of the University Hospital Careggi, Florence, Italy. Previous posts included 15 years as Professor of Clinical Cardiology at Imperial College of Sciences, Medicine & Technology, London and Consultant Cardiologist at the Royal Brompton Hospital. He also practiced at the San Raffaele Hospital, Milan, Italy. He trained in Cardiology at the University of Padova, Italy, but he soon moved for a more in-depth interventional trying at the Thoraxcentre of Rotterdam, the Netherlands, where he also complete a PhD in Intracoronary Ultrasound Imaging and Doppler. He maintains an active clinical involvement performing more than 200 PCI per year in the last 15 years in London with the special interest in the treatment of chronic total occlusions, bifurcations, calcified lesions and diffuse disease. He is a regular TAVI operator and certified implanter for the Medtronic Evolute R and Edwards Sapien 3 transcatheter aortic valves. He participated to more than 130 MitraClip implantations in London and in the last few months back in Italy has also started transcatheter mitral treatment with clips, valves and direct annuloplasty. Professor Di Mario pioneered the use of intracoronary Doppler, pressure measurement, ultrasound and optical coherence tomography. These techniques have become the gold standard for physiological assessment of lesion severity and have revolutionised the technique of stent implantation with the use of high pressure dilatation which led to the universal application of this method in interventional cardiology. Professor Di Mario is now applying these intravascular techniques for the guidance of implantation of fully bioabsorbable stents and optimal stent apposition across bifurcations and in complex lesions. He has led or participated in studies and trials to improve the technical success of recanalisation of chronic total occlusion and demonstrate its clinical usefulness. He cooperated with Dr J. Davies to the validation of iFR to assess lesion severity and discriminate the contribution of individual lesions, and with Dr A Lyon to the intracoronary delivery of SERCA-2 genes via adenoviral vectors in the CUPID2 trial. Prof Di Mario was Principal Investigator of the CARESS in AMI trial, a large multicentre trial showing that patients who receive fibrinolytic therapy for ST-elevation myocardial infarction benefit from early angioplasty. This trial and a subsequent meta-analysis have led to a change in the European Society of Cardiology and AHA/ACC Guidelines for treatment of STEMI patients. He is the PI and main recruiter of the Disrupt-CAD study with coronary lithotripsy delivered via dedicated balloons, due to be reported at ACC March 2017.

Dr Sayan SenProf Takashi Akasaka graduated from Wakayama Medical University in 1982 and finished his residency at Kobe City Medical Center General Hospital. He was  a clinical fellow at Harefield Hospital in the United Kingdom in 1987. Since 1989, he had done clinical research work in the field of coronary physiology using echocardiography, pressure wire and flow wire extensively at Kobe City Medical Center General Hospital as a director of cardiac catheterization laboratory for 8 years. After he moved to Kawasaki Medical School as an associate professor, he started OCT in addition to coronary physiology in 1999. He became Professor of Wakayama Medical University in 2005 and he has been devoted to the clinical research work using OCT. He has published many papers regarding the pathophysiology of ACS or DES healing process using OCT in collaboration with his colleagues in addition to coronary physiology research. Based on his clinical and research work, he has been an executive board member in various cardiology societies and a course co- director of several coronary live-demonstration courses in the world. 

Dr Rasha Al-Lamee

Dr Rasha Al-Lamee is an Interventional Cardiologist at Imperial College Healthcare NHS Trust in London, UK.  Dr Al-Lamee’s research interests are complex coronary intervention, coronary physiology and invasive intravascular assessment. She is currently leading the ORBITA trial as part of a PhD programme under the supervision of Dr Justin Davies and Professor Darrel Francis. At Imperial College is actively involved in the development and recruitment for a number of multi-centre clinical trials. Dr Al-Lamee has over 30 peer-reviewed publications and has presented at international Cardiology conferences worldwide throughout her clinical career. 

She studied at the University of Oxford and University College London. She went onto complete her training as a junior doctor on the Barts and the London Medical rotation before being appointed as a Specialist Registrar on the North West London Cardiology rotation in 2006.

Dr Al-Lamee has eleven years of Cardiology experience and completed three years of Interventional Fellowship training at Hammersmith Hospital in London. She also spent one year training as an Interventional Fellow under the supervision of Professor Antonio Colombo in Milan. She completed specialist training in Cardiology in 2013.

Dr Christopher Cook

Prof Javier Escaned is Consultant Interventional Cardiologist / Associate Professor and Head of Section, Cardiology Department, Hospital Clinico San Carlos (Madrid, Spain). He trained as a cardiologist the United Kingdom (Queen Elizabeth University Hospital, Birmingham and Walsgrave Hospital, Coventry) before moving to the Thoraxcenter / Rotterdam (The Netherlands), where he obtained his PhD degree in 1994. Author of more than 200 scientific articles, books and book chapters on different aspects of interventional cardiology, imaging and physiology, his latest contribution is the textbook “Coronary Stenosis. Imaging, Structure and Physiology”, co-edited with Patrick W Serruys. He is currently co-director or EuroPCR. Some of his additional interests are philosophy, education and music.

Dr John Davies

Dr Robert Gerber is a Consultant Cardiologist at both Conquest Hospital Hastings and Eastbourne District General Hospital in East Sussex Healthcare NHS Trust (ESHT). He graduated from Guy's, King's and St Thomas' Medical School which is part of King's College London in 2000. He was one of a select few that undertook the MB/PhD programme after being awarded the University of London Carpenter prize for Physiology 1994 and subsequently graduated with both academic and clinical qualifications. He holds dual accreditation in Cardiology and General Internal Medicine on the GMC specialist register and was awarded Fellowship of the Royal College of Physicians in 2014. He is also a member of the British Hypertension Society (BHS), the British Cardiovascular Intervention Society (BCIS) and the European Association of Percutaneous Coronary Intervention (EAPCI). His sub-specialty training in Interventional Cardiology was at Imperial College London (Hammersmith and St Mary's Hospitals) and the San Raffaele Hospital and Columbus Hospital in Milan. He is involved in Research and Teaching and is Module leader for the MSc in Cardiology at Brighton and Sussex University (BSUH). He has published extensively on interventional cardiology and has several published peer reviewed manuscripts on IVUS guided stenting, antiplatelet therapy and the long-term outcomes of PCI in multivessel coronary artery disease and the influence of gender on PCI outcomes. He is also the ESHT Principal Investigator of several randomised clinical trials (Atlantic, Pegasus, TAO, Flair, Orbita and Odyssey Outcomes). He enjoys cycling, skiing and triathlon.

Professor Carlo Do MarioDr Nieves Gonzalo, Born in Madrid, Spain in 1976. In 2006 she got the degree of Cardiologist after her training in Clinico San Carlos University Hospital in Madrid. After finishing her specialization she moved to Rotterdam in The Netherlands for a research fellowship in the Thoraxcenter, Erasmus University with the team of Professor Patrick Serruys. There, she worked mainly in intracoronary imaging techniques and bioabsorbable stents. In 2010 she obtained her PhD with the thesis “Optical coherence tomography for the assessment of coronary atherosclerosis and vessel response after stent implantation”. Currently she works in the Interventional Cardiology Department at Clinico San Carlos University Hospital in Madrid. 

Dr Nicolas Foin

Dr Allen Jeremias  is the Director of Interventional Cardiology Research and Associate Director of the Cardiac Catheterization Laboratory at St. Francis Hospital, Roslyn, NY. He was previously an Associate Professor and the Director of the Cardiac Catheterization Laboratory at Stony Brook University Medical Center. He is also a member of the Cardiovascular Research Foundation, New York, where he currently serves as the Director of the Physiology Core Laboratory.

Dr. Jeremias earned his medical degree at Heinrich-Heine-University School of Medicine in Düsseldorf, Germany, and a Master of Science degree at Harvard Medical School. He completed his Medical training at The Cleveland Clinic Foundation, Stanford University School of Medicine, as well as Beth Israel Deaconess Medical Center, Harvard Medical School.

Dr. Jeremias is board certified in cardiovascular medicine and interventional cardiology and is a Fellow of the American College of Cardiology as well as the Society for Cardiovascular Angiography and Interventions. Dr. Jeremias has numerous publications in the area of interventional cardiology and is the editor of the Medical text Cardiac Intensive Care. He is the author of Your Personal Guide to Angioplasty, a patient-centered book focusing on coronary artery disease and various treatment options. He also is the recipient of numerous awards, including Castle Connolly’s Top Doctors: New York Metro Area, 2009 – 2016.

Dr Allen Jeremias, M.D., M.Sc.

Jurgen Ligthart has been working on intervention cardiology as a Cath lab technician since 1982, firstly to support the cardiologists in working with X-rays and positioning, or “how to get better angiograms and less X-ray dosage”.
With the first IVUS performed in man in 1989, he was soon interested in invasive imaging and especially in the interpretation of the images or “what lies between the lumen and the media”. With IVUS initially used as research tool he was soon convinced that using IVUS (and later other modalities) can make a difference for patients. A standard acquisition protocol for all patients, no exceptions, was in his opinion a must but it took till 1997 before he implemented the standard acquisition protocol in Erasmus MC, which is still the standard of all invasive imaging procedures. With the standardisation he started to review, interpret and report IVUS procedures like a radiologist would do. In 2006, he developed for Erasmus MC the first 2 days interactive IVUS course for physicians, with live cases from the Cath lab. This formula is still used for all their invasive imaging courses (IVUS and OCT). In 2008, he developed an invasive imaging database in Erasmus MC that is still in use and growing, containing 4600 patients and 12000 pullbacks, available for viewing and reviewing at any time.
In 2011, he started a part time one man consultancy company (LIMIC Medical) customers: Boston Scientific, Philips Volcano, St. Jude Medical, Terumo, InfraredX, ACIST, Abbott and congress and course-organising hospitals.
Jurgen has had the great honour to work almost 35 years with Professor Patrick Serruys and also several years with Professor Carlo Di Mario, who was in Rotterdam his “partner in invasive imaging crime”.

Dr Iqbal Malik

Dr Iqbal Malik is an Honorary Senior lecturer at Imperial College London, and Consultant Interventional Cardiologist at Hammersmith and St Mary’s Hospitals. His research interests are in complex coronary disease and structural heart disease. He qualified from Cambridge University with a 1st Class degree, and then moved to Guys Hospital, London, winning the Golding Bird Medal as an undergraduate. He trained in Medicine and then Cardiology, before completing a PhD at Imperial College London, looking at the role of Inflammation in Coronary Artery Disease. He was awarded a BHF junior research fellowship for 3 years. He was appointed as a Consultant in 2003, having completed sabbaticals in Italy and Germany to hone his skills in Structural Heart Disease. He is clinical lead for the care of acute coronary syndromes and Structural Heart Disease at Imperial College Healthcare NHS trust, including the Transcatheter Valve (TAVI) and Septal Defect Closure programs. He has been involved with Simplephysiology since the inception of the concept of iFR as a way to simplify the use of coronary physiological assessment.  His meticulous verification of data with the more complex technique of coronary flow measurement, has allowed validation of the science behind iFR. Starting from normal arteries, simple and complex native coronary lesions, and bypass grafts, the group has now studied the effects of hemodynamic support device such as balloon pumps and Impella devices on coronary physiology. Next is the unique opportunity to assess the effect of immediate removal of aortic stenosis using TAVI!

Dr Allen Jeremias, M.D., M.Sc.

Dr Manesh Patel is cardiology section leader in Interventional Cardiology and is the Director of Cardiac Catheterization Laboratories for the Duke University Health System. Dr Patel previously served as the Director of Duke Cath Lab Research.  His clinical interests include diagnostic and interventional coronary angiography, peripheral angiography and percutaneous intervention. He is involved in several clinical trials involving patients with vascular disease and in cardiac imaging. He is also a member of the American College of Cardiology Task Force for Appropriate use of Cardiovascular Procedures and is Chair of the American Heart Association Diagnostic and Interventional Cath Committee. Patel’s interest in cardiac imaging, quality of care, and cardiac devices is also evident in his research. His integration of these efforts into his roles at Duke was recognised in 2010 when he received the prestigious Duke Cardiology Fellowship Mentorship Award.  In 2011, Dr Patel was named the endowed John Bush Simpson Assistant Professor of Cardiology.  

In 2013, Dr Patel took over the role of Director of Interventional Cardiology and the Cardiac Catheterization Laboratories for the Duke University Health System with the goal of integrating patient-centered invasive care across the health system. Dr Patel has published over 150 peer-reviewed articles in high impact journals, several reviews and over 20 editorials. Most recently, his articles in the Journal of the American College of Cardiology, Journal of the American Medical Association, and the New England Journal of Medicine garnered national attention from the scientific and lay press. Patel received his medical degree from Emory University School of Medicine in 1997. He completed his residency at Duke in 2000, followed by fellowships in cardiology and interventional cardiology at Duke University.

Dr Iqbal Malik

Dr Sayan Sen is a Cardiologist and NIHR Clinical Lecturer at Imperial College London. His research interests are dedicated to improving patient care. As such, they include the development and validation of new diagnostic tools, determining how the design of comparative efficacy studies can affect clinical use of competing therapies and the development and application of tools that permit a more patient centered approach to therapy. He studied Medicine at University College London (UCL), achieving a First Class (Honours) Bachelor of Science degree in Medical Sciences & Neuroscience in 2000 and graduated with distinction (Surgery) in his final MBBS Examinations in 2003. He trained as a junior doctor on the Hammersmith and UCL medical rotations prior to being appointed as a Cardiology Specialist Registrar in the North West London region in April 2006 and a NIHR clinical Lecturer in 2013. One of the themes of his research is to determine the need for potent vasodilators when assessing coronary stenosis severity. Working with Dr Justin Davies, Dr Sen’s PhD introduced and developed a new technique of stenosis evaluation (the instantaneous wave-free ratio, iFR). He is the first author of ADVISE and CLARIFY - two investigator lead studies that demonstrate the potential of iFR and challenge current concepts of coronary physiology. Currently, in addition to being the Principal Investigator of several first in man physiological studies, he is also the Medical Director of the FLAIR trial – a global multi-centre randomized study comparing iFR to existing techniques.

Dr Sukhjinder Nijjer

Prof  Patrick  Serruys with respected h-index – 157 is a professor of Interventional Cardiology at the Interuniversity Cardiological Institute of the Netherlands (1988-1998) and Erasmus MC. Since 1980 he was a Director of the Clinical Research Program of the Catheterization Laboratory, Thorax Center at Erasmus University, and till April 1, 2014 (retirement date) the Head of the Interventional Department, Thorax Center, Erasmus MC (University Medical Center Rotterdam), Rotterdam, The Netherlands. Since April 2013, he holds the position of Professor of Cardiology in the Cardiovascular Science Division of the National Heart and Lung Institute (NHLI) at the Faculty of Medicine, within the Imperial College of Science, Technology and Medicine, London.

He is a Fellow of the American College of Cardiology and a Fellow of the European Society of Cardiology and scientific council of the International College of Angiology.

In 1996, he received the TCT Career Achievement Award and in 1997 he was awarded the Wenkebach Prize of the Dutch Heart Foundation. In 2000, he was awarded the Gruentzig Award of the European Society of Cardiology. In 2001, he held the Paul Dudley White Lecture at the American Heart Association in the USA. In 2004, he received the Andreas Gruentzig Award of the Swiss Society of Cardiology. In 2005, he held the 4th International Lecture at the AHA and Mikamo Lecture at the Japanese heart Association. In 2006, he received the highest award of the Clinical Council of the American Heart Association: the James Herrick Award. In 2007, he received the Arrigo Recordati International Prize (Italy) and the ICI Achievement Award (bestowed by the President of Israel – Shimon Perez). In 2008, he received the Einthoven Penning (Leiden). In 2009, he became Doctor Honoris Causa from the University of Athens. In 2011, he received the Lifetime Achievement Award, bestowed by the American College of Cardiology, in recognition of many years of service and invaluable contributions to the ACC. At the end of 2011, Prof Serruys received the Ray C. Fish Award, bestowed by the Texas Heart Institute, for outstanding achievement and contribution to cardiovascular medicine. In 2012, he received a Golden Medal of the European Society of Cardiology. In 2013, he became Doctor Honoris Causa from the Complutense University of Madrid. In 2016, he will become Doctor Honoris Causa of the Melbourne University, Australia.

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Target Audience

Learning Objectives

We know that sometimes IVUS appears difficult to understand and look forward to making things Simple for you.


  • International faculty
  • Hands on experience (break-out sessions:
    • Assembling the kit
    • Making Measurements (iPad/computer)
    • Case practice with instructor support
  • Latest clinical evidence
  • Structured case-based lectures on identification of thrombus, dissection, malapposition and more
  • Live case demonstrations using IVUS co-registration

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