Novel Oral Anti-Coagulants (NOACs): Hot Topics & Current Issues

Roundtable
On 12 November 2014, Radcliffe Cardiology, in association with Arrhythmia & Electrophysiology Review (AER) journal, held a roundtable discussion in London, UK. The discussion held between an expert group of physicians was moderated by Professor A John Camm, a renowned authority in anticoagulation and atrial fibrillation. The meeting comprised a series of seven presentations and subsequent panel discussions on a range of topical issues related to the use of non-vitamin K antagonist (novel) oral anticoagulants (NOACs): real-world versus clinical trial data; once or twice daily dosing regimens; spot checks or monitoring for anticoagulation status; antidotes for NOACs; NOACs and dual antiplatelet therapy; NOAC treatment in chronic renal impairment; and choosing between NOACs. This paper summarises the presentations and presents key highlights from the subsequent discussions.

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Overview

The discussion was moderated by Professor A. John Camm (London, UK), a renowned authority in anticoagulation and atrial fibrillation, and an editorial board member of AER. He was joined by expert group of physicians including Doctor Marco Alings (Breda, NL), Professors Raffaele De Caterina (Chieti, IT), Paulus Kirchhof(Birmingham, UK), Jean-Yves Le Heuzey (Paris, FR) and Freek Verheugt (Amsterdam, NL).

The meeting comprised of seven presentations and subsequent panel discussions on a range of topical issues related to the use of non-vitamin K antagonist (novel) oral anticoagulants in various clinical scenarios.

  • SESSION 1 / Real-world versus clinical trial data with NOACs
  • SESSION 2 / Once or twice daily NOAC therapy: Theory and practice
  • SESSION 3 / Spot checks or monitoring of NOACs for anticoagulation status
  • SESSION 4 / Antidotes for NOAC drugs
  • SESSION 5 / NOACs and dual antiplatelet therapy
  • SESSION 6 / NOAC treatment in chronic renal impairment
  • SESSION 7 / How to choose between NOACs

Featuring

A. John Camm, Professor of Clinical Cardiology and Head of the Department of Cardiac and Vascular Sciences, St. George's Hospital Medical Centre, London, UK

Marco Alings, Director of the Cardiology Training Program, Amphia Ziekenhuis, Breda, The Netherlands

Raffaele De Caterina, Professor of Cardiology and Director of the University Cardiology Division, "G. d'Annunzio" University, Chieti, Italy

Paulus Kirchhof, Chair in Cardiovascular Medicine Cardiovascular and Respiratory Sciences, University of Birmingham, UK

Jean-Yves Le Heuzey, Professor of Cardiology and Head of the Arrhythmia Department, Georges Pompidou Hospital, Paris, France

Freek Verheugt, Chairman, Department of Cardiology, Onze Lieve Vrouwe Gasthuis (OLVG), Amsterdam, The Netherlands

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Target Audience

This educational activity is intended for an international audience of non-US healthcare professionals, specifically electrophysiologists and cardiologists. However, neurologists, internal medicine specialists, primary care physicians, and other healthcare professionals involved in the diagnosis and management of patients with atrial fibrillation (AF) will also find this topical.

The Novel Oral Anti-Coagulants (NOACs): Hot Topics & Current Issues roundtable was supported by an unrestricted educational grant by Daiichi-Sankyo.

Learning Objectives

The assigned learning objectives for this roundtable are listed for your information:

  • To review the established evidence-base for non-VKA thromboprophylaxis in atrial fibrillation (AF)
  • To consider recent and emerging data on non-VKA oral anticoagulants in AF trials and registries
  • To discuss on-going non-VKA oral anticoagulant research in patients with AF
  • To identify and refine the indications for specific non-VKA oral anticoagulants in AF
  • To establish the nature of further non-VKA oral anticoagulant research needed for new AF indications

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