Advanced Physiology Course (PARIS) - Module 1

Dr Justin Davies is a consultant 
interventional cardiologist at Hammersmith Hospital, Imperial College NHS Trust, London. After training at Imperial 
College, he won a prestigious BHF research fellowship to study arterial haemodynamics. Since then he has continued to
 work on the development of mathematical algorithms to aid 
understanding of large artery physiology and to develop new
 tools to assess arterial disease. The holder of several patents,
 he has published widely in the field of hypertension, coronary and large artery physiology and is the winner of many national and international awards. He has several international collaborations, and is the developer of iFR and the co-principal investigator of the ADVISE studies, the DEFINE-FLAIR, ORBITA and DEFINE-PCI studies. Justin also has an interest in renal denervation, and has lead the first-in-man studies to evaluate the safety of this technique to patients with chronic systolic heart failure (REACH studies). 

Prof Javier Escaned is Consultant Interventional Cardiologist / Associate Professor and Head of Section, Cardiology Department, Hospital Clinico San Carlos (Madrid, Spain). He trained as a cardiologist the United Kingdom (Queen Elizabeth University Hospital, Birmingham and Walsgrave Hospital, Coventry) before moving to the Thoraxcenter / Rotterdam (The Netherlands), where he obtained his PhD degree in 1994. Author of more than 200 scientific articles, books and book chapters on different aspects of interventional cardiology, imaging and physiology, his latest contribution is the textbook “Coronary Stenosis. Imaging, Structure and Physiology”, co-edited with Patrick W Serruys. He is currently co-director or EuroPCR. Some of his additional interests are philosophy, education and music.

Prof Pierre Lantelme is Professor of Cardiology at the Claude Bernard University of Lyon since 2003. He is appointed as Head of the department of Cardiology in two University Hospitals in Lyon and is a researcher at the INSERM/CNRS Creatis Laboratory. He was trained in Cardiology in Lyon and in Research in the US (Salt Lake City, UT). He has a strong physiological background, particularly concerning blood pressure signal and blood pressure regulation. He is currently the Head of the European Excellence Center for Hypertension in Lyon, the General Secretary of the French Society of Hypertension, and the Treasurer of the French Federation of Cardiology. His main research interest is focused on arterial stiffness. Part of his research has been conducted in the field of hypertension with some important advances in terms of prognostic implication of various indicators of aortic stiffness. As an interventional cardiologist, he has brought these concepts in the cath-lab. He has proposed new ways of assessing coronary biomechanics by measuring pulse wave velocity (a concept currently under patent). He is also interested in TAVI, exploring new score scores or strategies to predict outcomes and improve risk stratification. He is the co-authors of more than 130 publications in peer-reviewed journal or book chapters.

Dr Sayan Sen is a Consultant Interventional Cardiologist and
NIHR Clinical Lecturer at Imperial College London. His research
interests are dedicated to improving patient care. As such, they
include the development and validation of new diagnostic tools,
determining how the design of comparative efficacy studies can
affect clinical use of competing therapies and the development
and application of tools that permit a more patient centered
approach to therapy. He studied Medicine at University College London (UCL), achieving a First Class (Honours) Bachelor of Science degree in Medical Sciences & Neuroscience in 2000 and graduated with distinction (Surgery) in his final MBBS Examinations in 2003. He trained as a junior doctor on the Hammersmith and UCL medical rotations prior to being appointed as a Cardiology Specialist Registrar in the North West London region in April 2006 and a NIHR clinical Lecturer in 2013. One of the themes of his research is to determine the need for potent vasodilators when assessing coronary stenosis severity. Working with Dr Justin Davies, Dr Sen’s PhD introduced and developed a new technique of stenosis evaluation (the instantaneous wave-free ratio, iFR). In addition to being the Principal Investigator of several first in man physiological studies, he was also the Medical Director of the DEFINE FLAIR trial – a global multi-centre randomized study that has recently demonstrated the non-inferiority of iFR to FFR for revascularisation decision-making in over 2500 patients. 

Prof Eric Van Belle is Professor of Interventional Cardiology at the University of Lille and Head of Catheterization laboratories, Cardiology Department at the University Hospital of Lille.
He is a fellow of the French Society of Cardiology, the European Society of Cardiology and
the American College of Cardiology. A member of the European Association of Percutaneous Coronary Intervention (EAPCI) and a member of the director bureau of the French Working Group of Interventional Cardiology (GACI), he is the Director of the French Interventional Cardiology Training Program, and reviewer of multiple Medical Journals and Abstracts. 

His research interests include basics and clinical aspects of the outcome of high risk population such as diabetics and post-MI patients following percutaneous coronary interventions (PCI),
the use of biomarkers for risk prediction and therapeutic strati cation at the time of PCI, the role of angiogenesis and collateral circulation for endogenous cardiovascular repair and the use of gene therapy and stem cell therapy for regenerating cardiovascular function including myocardial and valve function. More recently it included also the optimization of transcatheter aortic valve intervention (TAVI), in particular the use of ore-procedural imaging and the understanding of the role post-procedural aortic regurgitation. This scienti c activity led to the publication of more than 100 publications in international scienti c journals with a total “H” index of 41. 

Prof. Van Belle clinical activities focus on prevention and treatment of complications of coronary atherosclerosis. It includes the management of a catheterization laboratory including 3 rooms and performing 2500 catheterization/year (CHU Lille). Personal activity in percutaneous coronary interventions (PCI) is 200-250 cases/year for the last 15 years and in transcatheter aortic valve intervention (TAVI) is 70-100 cases/ year for the last 4 years. 

He is one of the principal or co-principal investigators in Prime-FFR, DEFINE-REAL, R3F, WITAVI and SAVE studies, and a member of the steering committe in ANGES CLI Trial, BRAVO 2/3, DEFINE-FLAIR, FRANCE PCI, FRANCE-TAVI studies.