Simple Education Interventional Cardiology: Coronary Physiology Course (iFR, FFR, CFR, CT-FFR), September 2018, London

2 day course, September 10-11th 2018 London, W2 2EA

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Simple Education essential guides Advances in Coronary Physiology is the premier international course in coronary physiology. This is the 6th year this 5* rated course has been run which has quickly become established as the premier global interventional course in state-of-the-art coronary physiology. The course provides all you need to know to understand coronary physiology from learning the background basics of coronary physiology to understanding the clinical trial data and implementation of coronary physiology in the catheter laboratory. 

An online teaching resource, the Simple Education application, will give you access to video content from the days' talks, and a raft of other online educational and learning resources which continue your learning experience and  connect you with the interventional community after the course finishes.



Dr Justin Davies

Dr Justin Davies is a consultant 
interventional cardiologist at Hammersmith Hospital, Imperial College NHS Trust, London. After training at Imperial 
College, he won a prestigious BHF research fellowship to study arterial haemodynamics. Since then he has continued to
 work on the development of mathematical algorithms to aid 
understanding of large artery physiology and to develop new
 tools to assess arterial disease. The holder of several patents,
 he has published widely in the field of hypertension, coronary and large artery physiology and is the winner of many national and international awards. He has several international collaborations, and is the developer of iFR and the co-principal investigator of the ADVISE studies, the DEFINE-FLAIR, ORBITA and DEFINE-PCI studies. Justin also has an interest in renal denervation, and has lead the first-in-man studies to evaluate the safety of this technique to patients with chronic systolic heart failure (REACH studies). 

Dr Javier EscanedProf Javier Escaned is Consultant Interventional Cardiologist / Associate Professor and Head of Section, Cardiology Department, Hospital Clinico San Carlos (Madrid, Spain). He trained as a cardiologist the United Kingdom (Queen Elizabeth University Hospital, Birmingham and Walsgrave Hospital, Coventry) before moving to the Thoraxcenter / Rotterdam (The Netherlands), where he obtained his PhD degree in 1994. Author of more than 200 scientific articles, books and book chapters on different aspects of interventional cardiology, imaging and physiology, his latest contribution is the textbook “Coronary Stenosis. Imaging, Structure and Physiology”, co-edited with Patrick W Serruys. He is currently co-director or EuroPCR. Some of his additional interests are philosophy, education and music.

Dr Sayan SenDr Sayan Sen is an internationally recognised Interventional Cardiologist based at the Hammersmith Hospital, London. His clinical expertise encompasses both general and interventional cardiology. Dr Sen’s research interests involve both first in man and larger multi-centre clinical trials. His research has been published in leading medical journals and has changed clinical practice around the world. Dr Sen leads the Imperial NHS Trust Cardiology Service for Central and West London. He routinely performs complex coronary angioplasty and TAVI. He is recognised as an expert in intra-coronary physiology and intravascular imaging and often performs live cases to International Conferences. Dr Sen's academic interests are dedicated to improving patient care. As such, they include the development and validation of new diagnostic tools, determining how study design can influence the clinical use of competing therapies and the development and application of tools that permit a more patient centred approach to therapy. One of the themes of his research is to determine which patients should be treated with stents. His PhD pioneered a new technique of stenosis evaluation (the instantaneous wave-free ratio, iFR). This index has been globally adopted by physicians to help guide how they treat patients with coronary artery disease. He currently leads a PhD program examining coronary haemodynamics in patients with valve disease. Sayan teaches regularly, he is the course director of the Advanced Coronary Physiology Course for consultant cardiologists, which has been attended by hundreds of practicing interventional cardiologists from around the world. Dr Sen qualified from University College London with Distinction. In 2009 he was awarded the MRC Research Fellowship, to study haemodynamics in coronary artery bypass grafts, native coronary arteries and in patients with severe aortic stenosis. Sayan’s academic awards include the Royal Society of Medicine Investigator of the Year Award (All Sections, 2013), the Royal Society of Medicine President's Gold Medal (Cardiology section, 2013), the prestigious Imperial College Armstrong Medal and Prize (2012), the Young Investigator Award at the British Cardiac Intervention Society Advanced Coronary Intervention meeting (2012), and the Young Investigator Prize at the Translating Coronary Physiology and Biophysics to Clinical Applications Symposium, Amsterdam (2010).

Dr Rasha Al-Lamee

Dr Rasha Al-Lamee is an Interventional Cardiology Consultant at Imperial College Healthcare NHS Trust in London, UK. Dr Al-Lamee’s research interests are complex coronary intervention, coronary physiology and invasive intravascular assessment. She designed, conducted and led the ORBITA trial and is the lead author of the primary publication in The Lancet. At Imperial College, she is actively involved in the development and recruitment for a number of multi-centre clinical trials. Dr Al-Lamee has over 40 peer-reviewed publications and has presented at international Cardiology conferences worldwide throughout her clinical career. She studied at the University of Oxford and University College London. She went onto complete her training as a junior doctor on the Barts and the London Medical rotation before being appointed as a Specialist Registrar on the North West London Cardiology rotation in 2006. Dr Al-Lamee has twelve years of Cardiology experience and completed three years of Interventional Fellowship training at Hammersmith Hospital in London. She also spent a year training as an Interventional Fellow under the supervision of Professor Antonio Colombo in Milan. She completed specialist training in Cardiology in 2013.

Dr Christopher Cook

Dr Christopher Cook is a Medical Research Council Clinical
Fellow at Imperial College London, undertaking a PhD in
coronary physiology under the supervision of Dr Justin Davies.
He studied Medicine at University College London (UCL) and
graduated with Distinction (Clinical Medicine and Clinical
Sciences) in his final MBBS Examinations in 2009. He achieved
a First Class (Honours) Bachelor of Science degree in
Physiology undertaking a period of research at The Hatter
Cardiovascular Institute. He was awarded ‘The Dean’s List’ for outstanding performance in the Faculty of Life Sciences. In total he was awarded 17 prizes including the prestigious Gold Medal Medicine (proxime accessit). In 2014, he was awarded the Imperial Valve and Cardiovascular Course Young Investigator Prize. In 2015 he was awarded the inaugural EuroPCR’s Got Talent Award. In 2017 he was elected onto the EuroPCR Clinical Programme Committee.

Dr John Davies

 Prof Carlo Di Mario is Professor of Cardiology at the University of Florence and Director of the Structural 
Interventional Cardiology Division of the University Hospital Careggi, Florence, Italy. Previous posts included 15 years as 
Professor of Clinical Cardiology at Imperial College of Sciences,
Medicine & Technology, London and Consultant Cardiologist at 
the Royal Brompton Hospital. He also practiced at the San 
Raffaele University Hospital, Milan, Italy. He trained in Cardiology at the 
University of Padova, Italy, but he soon moved for interventional training at the Thoraxcentre of Rotterdam, the Netherlands, where he also completed a PhD in Intracoronary Ultrasound Imaging and Doppler. Despite his teaching, research and administrative commitments, he maintains an active clinical involvement performing more than 100 PCI per year with special interest in the treatment of calcified lesions, chronic total occlusions, bifurcations, and diffuse disease. He is a regular TAVI operator and certified implanter for the Medtronic Evolut R and Edwards Sapien 3 transcatheter aortic valves. He participated in more than 160 MitraClip implantations in London and Florence and has recently started direct annuloplasty with the CardioBand. Professor Di Mario pioneered the use of intracoronary Doppler, pressure measurement, intravascular ultrasound, optical coherence tomography, and near infrared spectroscopy. He was PI of the OPTICUS trial, failing to demonstrate superiority of IVUS guided stenting, and of the Lipid Rich Plaque study, due to report at TCT 2018. He was Principal Investigator of the DESTINI trial, using Doppler CRF to identify lesions in need of stenting, and of the CARESS in AMI trial, a large multicentre trial showing that patients who receive fibrinolytic therapy for ST-elevation myocardial infarction benefit from early angioplasty. This trial and a subsequent meta-analysis have led to a change in the European Society of Cardiology and AHA/ACC Guidelines for treatment of STEMI patients.

Prof Carlo Di Mario cooperated with Dr Davies to the validation of iFR to assess lesion severity and discriminate the contribution of individual lesions, and with Dr Lyon in the intracoronary delivery of SERCA-2 genes via adenoviral vectors in the CUPID2 trial. He was the main recruiter of the DISRUPT-I-CAD study and is PI of the DISRUPT-II trial, both pioneering the use of coronary lithotripsy for calcified coronary lesions.

Dr Sukhjinder Nijjer

Juliet Nilsson is the Creative Director of Simple Education, the online cardiology educational platform aggregating content from key courses, global intuitions and leaders in the field of interventional cardiology. She received a Master’s in Art History with Honours from Edinburgh University before joining the Creative Development team at Lightyears, Stockholm in 1998. Juliet continued in creative development in Copenhagen for the trail blazing e-commerce bureau AHEAD, and then as International Creative Director for Caput Community Software Solutions. Following a role as Senior Consultant at Halcyon Gallery in London and Copenhagen, Juliet founded Vind & Våg Publishing House in 2013, a creative development agency. Juliet has published several books under her own imprint and is currently the founder & advisor to the Nordic Art Agency.

Dr Ricardo Petraco

Dr Sukhjinder Nijjer is a Consultant Cardiologist with a specialist interest in Coronary Intervention and the treatment of coronary artery disease. He works at both Chelsea & Westminster NHS Foundation Trust and Imperial College Healthcare NHS Trust. Dr Nijjer is also an Honorary Clinical Senior Lecturer at Imperial College.

He has clinical research interests in coronary physiology and the treatment of acute coronary syndromes. He has a PhD awarded by Imperial College London in coronary blood flow and the use of stenting to treat complex stenoses. Clinically, he is specialises in interventional cardiology and he is skilled in coronary intervention and the application of coronary physiology and intravascular imaging. He has expertise in anti-platelets, optical coherence tomography and CT coronary angiography. He has specific research interests in coronary artery physiology and clinical trial design, and is working at the forefront of innovation in physiological assessment for coronary disease. He has presented his PhD research at the leading cardiology conferences around the world, including the European Society of Cardiology (ESC), Transcatheter Cardiovascular Therapeutics (TCT) and EuroPCR. He has won many awards and has over 70 high impact publications.

Dr Fausto Rigo

Dr Ricardo Petraco is a NIHR Lecturer in interventional Cardiology at Imperial College London, performing his clinical work at Hammersmith Hospital. He has been working with coronary physiology at Imperial since 2010 on the development of the novel instantaneous wave-Free Ratio (iFR). Dr Petraco’s work with iFR has led to the proposition of the Hybrid iFR-FFR approach and has established iFR’s close relationship with coronary flow reserve (CFR). His interests in computer programming has led to the development of a software for automated analysis of coronary haemodynamics signals which is been used by many leading centres in the world. He has also pioneered the algorithm for iFR calculation without the need for an ECG signal, an approach which is now implemented in clinical consoles. He has secured several research grants and published extensively in the field of coronary physiology. His current research interests are on the development of methodologies to assess stenosis severity in situations of haemodynamic instability and on the understanding of how medical therapies modulate coronary resistance and flow. Clinically, his interests also include the use of intravascular imaging modalities to optimise PCI and has been engaged in IVUS training for cathlab staff and cardiology trainees.

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Moment Components

Welcome and introductions to Advances in Coronary Physiology Course - Dr Justin Davies
Hot topics in coronary physiology: DEFINE-FLAIR iFR; SwedeHeart; Syntax II - Dr Justin Davies
Pressure derived indices of stenosis severity - Dr Ricardo Petraco
Live case transmission from Clinico San Carlos, Madrid, Spain - Prof Javier Escaned
Understanding mechanisms of regulation of resting and hyperaemic blood flow - Dr Christopher Cook
Getting the most out of our Advances in Coronary Physiology Courses: online-resources, and certification - Juliet Nilsson
DEFINE-FLAIR and iFR SwedeHeart study design and results - Prof Carlo Di Mario
Flow based indices of stenosis severity - Dr Justin Davies
How to perform iFR and FFR, and best-practice measurement tips and tricks - Dr Ricardo Petraco
Health Economic assessment using iFR and FFR to guide revascularization decision-making. - Dr Christopher Cook
Combined, patient-level pooled analysis of DEFINE-FLAIR and iFR SwedeHeart and safety of deferral in stable coronary disease and ACS. Does flow underlie the results? - Dr Justin Davies
Understanding mismatch between iFR and FFR from DEFINE-FLAIR and iFR SwedeHeart using pressure and flow and exercise physiology data. - Dr Christopher Cook
Safety of deferral in LAD, and non-LAD vessels using iFR and FFR guide approach - Dr Sayan Sen
DEFINE-FLAIR and iFR SwedeHeart: Implication for guidelines and evaluation of coronary ischaemia - Prof Carlo Di Mario
Case study - Dr Justin Davies
Should stenting be used at all? Results and impact from ORBITA - Dr Rasha Al-Lamee
Lessons learned from the 2-year results of SYNTAX II - Prof Javier Escaned
Live case transmission from Hammersmith Hospital
Should we be treating a number? Moving from vessel level ischaemia to stenosis level assessment. Are we missing physiologically significant stenoses? - Dr Justin Davies
Understanding SyncVision Co-registration and why it’s important to distinguish between focal and diffuse coronary disease - Dr Sukhjinder Nijjer
Using iFR Co-registration to plan revascularization decision-making: Cases examples - Dr Sukhjinder Nijjer
Using digital algorithms and AI to improve physiological measurement and data interpretation - Dr Justin Davies
Should we be using a dichotomous cutpoint and what is the meaning of an FFR >0.80 - Prof Javier Escaned
Physiological assessment in coronary stenosis pre TAVI - Dr Sukhjinder Nijjer
Is it still too early to use CT-FFR and angio-FFR in the catheter laboratory in 2018? - Dr Justin Davies
The value of intracoronary physiology in acute coronary syndromes - Prof Javier Escaned
How does right atrial pressure impact physiological assessment? - Dr Ricardo Petraco

Target Audience

This essential guide is an educational activity intended for an international audience, specifically interventional cardiologists and cardiologists. However, other healthcare professionals involved in the care of coronary artery disease (CAD) patients will also find this topical. 

This 2 day course general admission pass which covers  registration, meals, and refreshments.  After course free access to online course resources including powerpoint images, course videos, and links to other Simple Education resources.

Learning Objectives

Advances in Coronary Physiology course provides all you need to know to understand the basics of coronary physiology and what you need to do to implement coronary physiology into the cardiac catheter laboratory.

  • Understanding the background of coronary physiology

  • Understanding of coronary blood flow regulation in unobstructed and obstructed coronary arteries

  • Learn what you need to know to implement iFR and FFR in your laboratory 

  • Learn about the guidelines for appropriate use and reimbursement

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