Sleep-disordered breathing (SDB), either obstructive sleep apnoea (OSA) or central sleep apnoea (CSA)/Cheyne-Stokes respiration (CSR) and often a combination of the two, is highly prevalent in patients with heart failure (HF), is associated with reduced functional capacity and quality of life, and has a negative prognostic impact. European HF guidelines identify that sleep apnoea is of concern in patients with HF. Continuous positive airway pressure is the treatment of choice for OSA, and adaptive servoventilation (ASV) appears to be the most consistently effective therapy for CSA/CSR while also being able to treat concomitant obstructive events. There is a growing body of evidence that treating SDB in patients with HF, particularly using ASV for CSA/CSR, improves functional outcomes such as HF symptoms, cardiac function, cardiac disease markers, exercise tolerance and quality of life. However, conflicting results have been reported on ‘hard’ outcomes such as mortality and healthcare utilisation, and the influence of effectively treating SDB, including CSA/CSR, remains to be determined in randomised clinical trials. Two such trials (SERVE-HF and ADVENT-HF) in chronic stable HF and another in post-acute decompensated HF (CAT-HF) are currently underway.
Martin R Cowie - Professor of Cardiology at National Heart and Lung Institute, Imperial College and Royal Brompton Hospital, London
Holger Woehrle - Medical Director at ResMed Science Centre, Martinsried and Consultant, Sleep and Ventilation Centre Blaubeuren, Blaubeuren
Olaf Oldenburg - Senior Cardiologist at Department of Cardiology, Heart and Diabetes Centre North Rhine-Westphalia, Ruhr University Bochum, Bad Oeynhausen, Germany
Thibaud Damy - Henri Mondor Hospital, Créteil, France
Peter van der Meer - University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Erland Erdmann - Director at Department of Internal Medicine III, Heart Centre, University of Cologne, Cologne, Germany © T
Marco Metra - Professor at Institute of Cardiology, University of Brescia
Faiez Zannad - Academic Hospital (CHU), Nancy, France
Jean-Noel Trochu - University Hospital (CHU), Nantes, France
Lars Gullestad - Oslo University Hospital, Rikshospitalet, Norway
Michael Fu - Sahlgrenska University Hospital/Östra Hospital, Göteborg, Sweden
Michael Böhm - Department for Internal Medicine III, University Hospital of the Saarland
Angelo Auricchio - Director of Electrophysiology in the Division of Cardiology at Fondazione Cardiocentro Ticino in Lugano in Switzerland
Patrick Levy - University Grenoble Alpes, Grenoble, France
