Conclusions and Clinical Perspective

↳ This is a section part of Moment: Takotsubo Cardiomyopathy

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Summary

Conclusion

TTC is an acute, reversible form of catecholamine stress-induced cardiomyopathy that mimics acute MI, and predominates in post- menopausal women. It presents with signs and symptoms of ischaemia and acute left ventricular dysfunction with regional wall motion abnormalities in the setting of no obstructive coronary artery disease. An emotional or physical stressor usually precedes TTC. The syndrome has a good prognosis although a few percentage of patients experience recurrent events. Mechanisms implicated in TTC include multi-vessel coronary spasm, endothelial and coronary microvascular dysfunction and direct catecholamine toxicity. Clinicians should be aware of this syndrome and studies that investigate mechanistic pathways of TTC may help with development of preventive and management strategies.

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